Disease Information

MGUS is a precursor condition where abnormal plasma cells produce a small amount of abnormal protein but don't yet cause problems. About 1% of MGUS cases progress to myeloma each year, so regular monitoring is important.

SMM is an intermediate stage between MGUS and active myeloma. There are more abnormal plasma cells and protein than in MGUS, but no organ damage yet. Some patients remain stable for years; others progress more quickly to active myeloma.

Active myeloma requires treatment when it begins causing "CRAB" symptoms: elevated Calcium, Renal (kidney) problems, Anemia, or Bone lesions. Modern combination therapies have significantly improved survival, and many patients achieve deep remissions.